Center for Sports Medicine & Orthopaedics
OrthoBiologics Program

OrthoBiologics are natural, tissue-derived compounds that can help your body heal more quickly and restore function. They are specialized technologies used to create living, functional tissues to replace or repair tissue that has been lost due to damage, disease or hereditary defects. OrthoBiologics are used alongside other treatments, like physical therapy and pain management techniques, as an alternative solution to or in combination with surgery for arthritis, injured muscles and many other common orthopaedic pains.

Individuals who are struggling with limited mobility due to arthritis, injury, tendinopathy (disease of the tendons), or other forms of musculoskeletal inflammation may experience relief and reduce the need for surgery by harnessing the healing potential of their own cells.

Platelet Rich Plasma

Commonly referred to as PRP, platelet rich plasma utilizes a patient’s own blood as a source of growth factors, proteins and natural anti-inflammatory agents. Growth factors are naturally occurring proteins that bind to the cells in your body and stimulate growth, healing, and repopulation. With this minimally invasive procedure, a doctor will draw the patient’s blood and spin it in a centrifuge to separate the blood into layers. The layer, which is rich with growth factors and platelets, is extracted and reintroduced into the damaged joint to encourage healing and reduce inflammation.

Adipose-Derived Cell Therapies

This method utilizes fat cells, which have high concentrations of messenger cells and other growth factors within them, to decrease inflammation and aid in healing. In a minimally invasive procedure, a doctor will retrieve a patient’s own fat cells and deposit them into a device that uses a saline agent to rid the cells of blood and oil. At that point, the fat tissue is micronized, creating an autograft that holds the ideal material and performance properties to stimulate healing. The doctor will then inject the fat graft into the joint experiencing the arthritic pain to decrease inflammation and encourage healing.

Bone Marrow Aspirate

Bone marrow – the soft, spongy tissue found in the center of large bones – is composed of both fluid and solid matter. It is rich in growth factors and messenger cells. Unlike other cells in the body, these cells are able to replicate themselves into various types of tissue for healing. To utilize bone marrow to stimulate healing and regrowth in an arthritic joint, a doctor will extract bone marrow fluid (called aspirate) from a healthy bone in the body, generally the pelvis, and place it in a centrifuge to generate a concentration of powerful cells. These cells are then reintroduced into the arthritic joint to repair damaged tissue and decrease inflammation.
These procedures are some of the newest treatments available today. They offer patients a minimally invasive option to help relieve the pain of arthritis or injury and improve function. Our highly skilled medical doctors use state-of-the-art diagnostic tools, including musculoskeletal ultrasound, high-definition on-site MRI, and X-ray, to obtain pinpoint accuracy during the procedures.

What You Should Know Before Getting Stem Cell Therapy

CSMO utilizes OrthoBiologics technology to create living, functional tissues to replace or repair tissue that has been lost due to damage, disease, or hereditary defects. For those struggling with limited mobility due to arthritis, injury, tendinopathy (disease of the tendons), or other forms of musculoskeletal inflammation, patients may be able to experience relief and avoid surgery by harnessing the healing potential of their own cells.

Most of the procedures are completed at one of our Surgical locations. However, the PRPs are done in the clinical setting.


For procedures completed at our Surgical centers you will be under a mild anesthetic. PRPs in the office you will be awake, and no anesthetic needed.

No. Commercial insurance companies deem OrthoBiologic procedures as an elective procedure and investigational and therefore do not cover these procedures.

Yes. OrthoBiologic procedures conducted by CSMO are safe. Patient safety is our top priority.

We will set up a consultation with one of our OrthoBiologic physicians who will go through an examination and current X-rays. Our physicians will then provide you with the best treatment options for you.

Yes. It is recommended that you stop taking any non-steroidal anti-inflammatory medications (NSAIDs) 2-3 weeks before and after the procedure. These medications work by blocking the activity of the growth factors in PRP and may decrease its effectiveness. Tylenol, however, works in a different way and may be used before or after the procedure.

4-6 weeks typically

CSMO offers several OrthoBiologic options. Please contact us at (423) 697-8780 to discuss these options and what will fit your individual needs.

Yes. Care Credit provides our patients the option to make monthly payments on any out of pocket expenses. Learn More at

Advanced Healing Options

CSMO’s OrthoBiologics program offers a variety of innovative services, including nonsurgical treatment, interventional pain management and rehabilitation. Our highly trained specialists will work with you to determine the best treatment plan options. Call (423) 697-8780 or email to learn more.

Areas Treated with OrthoBiologics

  • Knee
  • Shoulder
  • Hand & Wrist
  • Hip
  • Elbow
  • Spine

Innovative Treatment

The physicians at Center for Sports Medicine and Orthopaedics are highly regarded as leaders in their profession. We offer patients the latest medical procedures and treatments that lead to the best possible outcomes. We are excited to offer our patients these innovative approaches to effectively treating pain and facilitate healing. Call (423) 697-8780 to schedule an appointment today.

OrthoBiologics Physicians


“I have been utilizing the medical staff at Sports Medicine for several years due to my pain from osteoarthritis.  I have been happy with the professionalism from each medical doctor and staff associated with them.  After having numerous injections and then meniscus repair on both knees I was approaching the thought of partial knee replacement.  Having the option to use stem cell injection was very exciting to me since I felt it was an alternative step before surgical replacement. I was completely satisfied with the care from Dr. Smalley and his staff from the time of getting the injections at the surgical center through the 2 months of follow up.   I would recommend the procedure to anyone who wants to utilize alternative options for pain.” – Theresa Averbeck